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Title 

Tissue-specific effect of ascorbic acid supplementation on the expression of cytochrome P450 2E1 and oxidative stress in streptozotocin-induced diabetic rats

Authors 

T AhnC H YunDoo-Byoung Oh

Publisher 

Elsevier

Issue Date 

2006

Citation 

Toxicology Letters, vol. 166, no. 1, pp. 27-36

Keywords 

ascorbic acidCYP2E1diabetesoxidative stressstreptozotocincytochrome P450cytochrome P450 2E1animal tissuebrain tissueprotein expression

Abstract 

Here, we investigated the effect of l-ascorbic acid (AA) supplementation on the CYP2E1 expression level and oxidative stress in various tissues such as the liver, kidney, pancreas, and brain of streptozotocin (STZ)-induced diabetic rats. An increased cytochrome P450 2E1 (CYP2E1) expression level with a concomitant increase in the production of reactive oxygen species were found in all the tissues of STZ-induced diabetic rats tested compared with an untreated control, suggesting the possible diabetes-induced tissue injury. In contrast, the AA supplementation to the diabetic rats alleviated these experimental parameters in a tissue-specific manner. AA affected the liver most severely followed by the kidney. There was little or no effect of AA supplementation on the brain and pancreas. The circulation level of the ketone bodies, inducers of CYP2E1, was also decreased by AA supplementation compared with those of the diabetic rats. Therefore, the suppression of ketone production by AA can be one of the mechanisms of a reduction in CYP2E1. These results suggest that AA plays an important role in reducing elevated CYP2E1 expression level and the oxidative stress mediated by type 1 diabetes with a tissue-specific variation.

ISSN 

0378-4274

Link 

http://dx.doi.org/10.1016/j.toxlet.2006.05.009

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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