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Title 

Anti-atherosclerotic and anti-inflammatory activities of catecholic xanthones and flavonoids isolated from Cudrania tricuspidata

 

꾸지뽕나무로부터 분리한 카테콜릭잔톤 및 플라보노이드 항동맥경화 및

Authors 

K H ParkYong-Dae ParkJong Min HanK R ImB W LeeI Y JeongTae Sook JeongWoo Song Lee

Publisher 

Elsevier

Issue Date 

2006

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 21, pp. 5580-5583

Keywords 

ACAT inhibitorLDL-antioxidantnitric oxideRAW264.7 cellscatechol xanthoneflavonoidxanthone derivativeantiinflammatory activityantioxidant activitycudrania tricuspidata

Abstract 

The catecholic xanthones and flavonoids 1-13 were isolated from the root bark of Cudrania tricuspidata. Compounds 1 and 3-8 exhibited significant antioxidant activity against low-density lipoprotein (LDL) oxidation in the thiobarbituric acid-reactive substance (TBARS) assay. Among them, prenylated flavonoids 10-12 showed an inhibitory effect on the NO production and iNOS expression in RAW264.7 cells. Also, compounds 1, 2, 5, 7, 9, and 11 preferentially inhibited hACAT-2 than hACAT-1, whereas compounds 3, 4, 6, and 8 showed a similar specificity against hACAT-1 and -2. However, flavonoids 10, 12, and 13 dominantly inhibited hACAT-2, not hACAT-1.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2006.08.032

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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