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Title 

Free radical scavengers from the medicinal mushroom Inonotus xeranticus and their proposed biogenesis

Authors 

In-Kyoung LeeJin-Young JungS J SeokW G KimBong Sik Yun

Publisher 

Elsevier

Issue Date 

2006

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 21, pp. 5621-5624

Keywords 

biogenesisfree radical scavengerhispidin derivativeinonotus xeranticusmushroomscavengerfree radical scavengers

Abstract 

New free radical scavengers, inoscavin D (1) and methylinoscavin D (2), were isolated from the methanolic extract of the fruiting bodies of Inonotus xeranticus (Hymenochaetaceae), along with the known compounds phelligridin D (3), 3,4-dihydroxybenzaldehyde (4), and 3,4-dihydroxybenzoic acid (5). Their structures were established by various spectroscopic analyses. Compounds 1 and 3 were proposed to be biosynthesized from the oxidative coupling of the precursor hispidin with 3,4-dihydroxybenzaldehyde and 3,4-dihydroxybenzoic acid, respectively. These compounds exhibited significant scavenging activity against the ABTS radical cation, and compounds 2 and 4 displayed moderate superoxide radical scavenging activity.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2006.08.016

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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