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Title 

Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice

Authors 

Ki Hoan NamJ H ChoiY J SeoY M LeeY S WonM R LeeM N LeeJ G ParkY M KimHyoung-Chin KimChul Ho LeeHyeong Kyu LeeSei Ryang OhG T Oh

Publisher 

Korean Society of Medical Biochemistry

Issue Date 

2006

Citation 

Experimental and Molecular Medicine, vol. 38, no. 4, pp. 445-452

Keywords 

anti-inflammatory agentshyperlipoporoteinemianitric oxidenitric oxide synthase type IItilianininducible nitric oxide synthaselow density lipoprotein receptorgene expression regulationknockout mouse

Abstract 

We investigated the effect of tillanin upon inducible nitric oxide synthesis in the plasma of low-density lipoprotein receptor knock-out (Ldlr-/-) mice fed with high cholesterol diet and in primary peritoneal macrophages of Ldlr-/- mice. High cholesterol diet induced nitric oxide production in the plasma of Ldlr-/- mice. Tilianin reduced the level of nitric oxide (NO) in plasma from Ldlr-/- mice induced by the high cholesterol diet. Tilianin also inhibited the NO production from the primary culture of peritoneal macrophages treated with lipopolysaccharide. The inhibition of NO production was caused by the suppression of inducible nitric oxide synthase (iNOS) gene expression in Peritoneal macrophages isolated from Ldlr-/- mice. Moreover, tilianin inhibited the transcriptional activation of iNOS promoter that has NF-κB binding element. Thus, these results provide the first evidence that tilianin inhibit iNOS expression and production of NO and may act as a potential anti-inflammatory agent.

ISSN 

1226-3613

Link 

http://dx.doi.org/10.1038/emm.2006.52

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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