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Title 

Fine-scale map of encyclopedia of DNA elements regions in the Korean population

Authors 

Y K YooX KeS HongH Y JangK ParkS KimT J AhnY D LeeO SongN Y RhoM S LeeY S LeeJ KimYoung Joo KimJ M YangK SongK KimmB WeirL R CardonJ E LeeJ J Hwang

Publisher 

Genetics Society of America

Issue Date 

2006

Citation 

Genetics, vol. 174, no. 1, pp. 491-497

Keywords 

DNA determinationDNA recombinationpopulation geneticschromosome mappingDNAgenetics, population

Abstract 

The International HapMap Project aims to generate detailed human genome variation maps by densely genotyping single-nucleotide polymorphisms (SNPs) in CEPH, Chinese, Japanese, and Yoruba samples. This will undoubtedly become an important facility for genetic studies of diseases and complex traits in the four populations. To address how the genetic information contained in such variation maps is transferable to other populations, the Korean government, industries, and academics have launched the Korean HapMap project to genotype high-density Encyclopedia of DNA Elements (ENCODE) regions in 90 Korean individuals. Here we show that the LD pattern, block structure, haplotype diversity, and recombination rate are highly concordant between Korean and the two HapMap Asian samples, particularly Japanese. The availability of information from both Chinese and Japanese samples helps to predict more accurately the possible performance of HapMap markers in Korean disease-gene studies. Tagging SNPs selected from the two HapMap Asian maps, especially the Japanese map, were shown to be very effective for Korean samples. These results demonstrate that the HapMap variation maps are robust in related populations and will serve as an important resource for the studies of the Korean population in particular.

ISSN 

0016-6731

Link 

http://dx.doi.org/10.1534/genetics.105.052225

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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