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Title 

Expression of the RERG gene is gender-dependent in hepatocellular carcinoma and regulated by histone deacetyltransferases

Authors 

A G WangW FangY H HanSang-Mi ChoJ Y ChoiK H LeeW H KimJ M KimM G ParkDae Yeul YuNam-Soon KimD S Lee

Publisher 

Korean Academy of Medical Sciences

Issue Date 

2006

Citation 

Journal of Korean Medical Science, vol. 21, no. 5, pp. 891-896

Keywords 

carcinoma, hepatocellularhistone acetyltransferasesras-related estrogen-regulated and growth-inhibitory gene (RERG)sexhistone deacetylasegene expression regulationgeneticsoncogene rasgene expression regulation, neoplasticgenes, ras

Abstract 

Ras-related, estrogen-regulated, and growth-inhibitory gene (RERG) is a novel gene that was first reported in breast cancer. However, the functions of RERG are largely unknown in other tumor types. In this study, RERG expression was analyzed in hepatocellular carcinomas of human patients using reverse transcriptase PCR analysis. In addition, the possible regulation of RERG expression by histone deacetyltransferases (HDACs) was studied in several cell lines. Interestingly, the expression of RERG gene was increased in hepatocellular carcinoma (HCC) of male patients (57.9%) but decreased in HCC of females (87.5%) comparison with paired peri-tumoral tissues. Moreover, RERG gene expression was increased in murine hepatoma Hepa1-6 cells, human breast tumor MDA-MB-231 cells, and mouse normal fibroblast NIH3T3 cells after treated by HDAC inhibitor, trichostatin A. Our results suggest that RERG may function in a gender-dependent manner in hepatic tumorigenesis and that the expression of this gene may be regulated by an HDAC-related signaling pathway.

ISSN 

1011-8934

Link 

http://dx.doi.org/10.3346/jkms.2006.21.5.891

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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