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Title 

Inhibitory effect of peroxiredoxin II (Prx II) on Ras-ERK-NFκB pathway in mouse embryonic fibroblast (MEF) senescence

Authors 

Y H HanJung Hun KwonDae Yeul YuE Y Moon

Publisher 

Informa Healthcare

Issue Date 

2006

Citation 

Free Radical Research, vol. 40, no. 11, pp. 1182-1189

Keywords 

ERKMEFNFκBperoxiredoxin IIrasROSbeta galactosidaseimmunoglobulin enhancer binding proteinmitogen activated protein kinase inhibitorperoxiredoxin

Abstract 

Intracellular reactive oxygen species (ROS) were attenuated by the expression of peroxiredoxin II (Prx II). Cellular senescence as judged by senescence-associated (SA)-β-galactosidase (Gal) positive cell formation was increased in Prx II-deficient mouse embryonic fibroblast (MEF). Ras expression was increased following passages. The level of Ras expression was higher in Prx II-/- MEF than wild type MEF. ERK activity was also augmented by the deletion of Prx II. SA-β-Gal-positive cell formation was reduced by PD98059, ERK inhibitor. Activated nuclear transcription factor, nuclear factor-kappaB (NFκB) by the deletion of Prx II was inhibited by the treatment with PD98059. In contrast, no changes in SA-β-Gal-positive cell formation were detected by NFκB inhibitor, N-alpha-tosyl-l-phenylalanyl chloromethyl ketone (TPCK). Collectively, results suggest that Prx II deletion activate Ras-ERK-NFκB pathways and cellular senescence in Prx II-/- MEF cells was mediated by ERK activation but not by NFκB activation.

ISSN 

1071-5762

Link 

http://dx.doi.org/10.1080/10715760600868552

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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