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Title 

Functional polymorphism 57Val>Ile of aurora kinase A associated with increased risk of gastric cancer progression

Authors 

H JuH ChoYong Sung KimW H KimC IhmS M NohJ B KimD S HahnB Y ChoiC Kang

Publisher 

Elsevier

Issue Date 

2006

Citation 

Cancer Letters, vol. 242, no. 2, pp. 273-279

Keywords 

advanced gastric cancercase-control studydisease severity associationsingle nucleotide polymorphismSTK15/Aurora-A/BTAKaurora A kinaseisoleucine transfer RNA ligasephenylalanineprotein kinasevaline

Abstract 

Overexpression or amplification of the aurora kinase A (AURKA) gene induces chromosomal instability and transformation. AURKA SNPs are associated with several human cancers but their association with gastric cancer has yet to be investigated. In this study, 501 gastric cancer patients and 427 controls were genotyped for two coding SNPs in AURKA, 91A>T (31Ile>Phe) and 169G>A (57Val>Ile). Allele or genotype association with gastric cancer susceptibility was not observed in comparisons between the patient and control samples. However, 169G/G genotype was significantly more frequent in advanced gastric cancers than in early gastric cancers (age/sex-adjusted OR=2.2, 95% CI=1.3-3.8, P=0.0042). Moreover, the elevated risk of gastric cancer progression was associated with 91T-169G (age/sex-adjusted OR=1.9, 95% CI=1.1-3.4, P=0.025) and 91A-169G (age/sex-adjusted OR=1.6, 95% CI=1.0-2.6, P=0.048) haplotypes, having ∼2.5-fold higher kinase activity than 91T-169A haplotype. The results suggest that 169G>A in AURKA is associated with progression of gastric cancer by affecting relative kinase activities of AURKA variants.

ISSN 

0304-3835

Link 

http://dx.doi.org/10.1016/j.canlet.2005.11.015

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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