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Title 

Hormonal activity of AIMP1/p43 for glucose homeostasis

Authors 

S G ParkY S KangJ Y KimC S LeeY G KoW J LeeK U LeeYoung Il YeomS Kim

Publisher 

National Academy of Sciences

Issue Date 

2006

Citation 

Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 40, pp. 14913-14918

Keywords 

aminoacyl-tRNA synthetaseglucagonpancreas

Abstract 

AIMP1/p43 is known as a cytokine working in the control of angiogenesis, inflammation, and wound healing. Here we report its enrichment in pancreatic a cells and glucagon-like hormonal activity. AIMP1 is secreted from the pancreas upon glucose starvation. Exogenous infusion of AIMP1 increased plasma levels of glucose, glucagon, and fatty acid, and AIMP1-deficient mice showed reduced plasma glucose levels compared with the wild-type mice under fasting conditions. Thus, AIMP1 plays a glucagon-like role in glucose homeostasis.

ISSN 

0027-8424

Link 

http://dx.doi.org/10.1073/pnas.0602045103

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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