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Title 

8-Hydroxydihydrochelerythrine and 8-Hydroxydihydrosanguinarine with a potent acetylcholinesterase inhibitory activity from Chelidonium majus L.

Authors 

K M ChoIck Dong YooWon Gon Kim

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2006

Citation 

Biological & Pharmaceutical Bulletin, vol. 29, no. 11, pp. 2317-2320

Keywords 

8-hydroxydihydrochelerythrine8-hydroxydihydrosanguinarineacetylcholinesterasechelidonium majus L.8 hydroxydihydrochelerythrine8 hydroxydihydrosanguinarinechelidonium extractcholinesteraseunclassified drugcontrolled study

Abstract 

Ethanol extract of the aerial portion of Chelidonium majus L. inhibited acetylcholinesterase (AChE) activity without a significant inhibition of butyrylcholinesterase (BuChE). Using mass spectrometry and NMR studies, three active constituents were isolated and identified: 8-hydroxydihydrochelerythrine (1), 8-hydroxydihydrosanguinarine (2), and berberine (3). Compounds 1-3 showed potent inhibitory activity against AChE, with IC50 (μmM) values of 0.61-1.85. Compound 1 exhibited competitive and selective inhibition for AChE.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.29.2317

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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