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Title 

Mouse transthyretin-related protein is a hydrolase which degrades 5-Hydroxyisourate, the end product of the uricase reaction

Authors 

You Ra LeeByoung Chul ParkDo Hee LeeKwang-Hee BaeS ChoC H LeeJong Suk LeeP K MyungSung Goo Park

Publisher 

Springer Verlag (Germany)

Issue Date 

2006

Citation 

Molecules and Cells, vol. 22, no. 2, pp. 141-145

Keywords 

hydroxyisouratetransthyretin-related proteinsuric aciduricaseargininehydrolasehydroxyisourate hydrolaseprealbuminurate oxidase5 hydroxyisourate

Abstract 

Uric acid is the end product of the purine degradation pathway in humans. It is catabolized to allantoin by urate oxidase or uricase (E.C. 1.7.3.3.) in most vertebrates except humans, some primates, birds, and certain species of reptiles. Here we provide evidence that mouse transthyretin-related protein facilitates the hydrolysis of 5-hydroxyisourate, the end product of the uricase reaction. Mutagenesis experiments showed that the residues that are absolutely conserved across the TRP family, including His11, Arg51, His102, and the Cterminal Tyr-Arg-Gly-Ser, may constitute the active site of mTRP. Based on these results, we propose that the transthyretin-related proteins present in diverse organisms are not functionally related to transthyretin but actually function as hydroxyisourate hydrolases.

ISSN 

1016-8478

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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