상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Dykellic acid inhibits cell migration and tube formation by RhoA-GTP expression

 

다이켈릭산이 RhoA-GTP 발현에 의해 세포이동과 tube 형성을 저해

Authors 

J C HeoJ Y ParkS U WooJ R RhoHo Jae LeeSung Uk KimYung Hee KhoS H Lee

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2006

Citation 

Biological & Pharmaceutical Bulletin, vol. 29, no. 11, pp. 2256-2259

Keywords 

angiogenesiscell migrationdykellic acidinvasionRhoARhoA-GTPRhoA guanine nucleotide binding proteinanimal cellcell invasion

Abstract 

Dykellic acid, a novel factor initially identified from the culture broth of Westerdykella multispora F50733, has been shown to inhibit matrix metalloprotease 9 activity, caspase-3 activity, B cell proliferation and LPS-induced IgM production, suggesting that this factor may have anti-cancer effects. In an effort to further address the possible anti-tumoral effects of dykellic acid, we used wound healing, invasion and RhoA-GTP assays to examine the effects of dykellic acid on cell migration, invasion and angiogenesis. Our results revealed that dykellic acid dose-dependently inhibits B16 cell migration and motility, and inhibits HUVEC tube formation. Western blot analysis of the active form of RhoA (RhoA-GTP) showed that dykellic acid treatment decreased the levels of RhoA-GTP. These findings collectively suggest that dykellic acid may have both anti-metastatic and antiangiogenic acitivites, and provides the first evidence for the involvement of RhoA in dykellic acid-induced effects.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.29.2256

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


Files in This Item: SizeFormat
6678.pdf764KbAdobe PDF
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)