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Title 

PTEN modulates hepatitis B virus-X protein induced survival signaling in Chang liver cells

Authors 

S Kang-ParkJi-Hye LimJ H LeeYoung Ik Lee

Publisher 

Elsevier

Issue Date 

2006

Citation 

Virus Research, vol. 122, no. 1, pp. 53-60

Keywords 

anti-apoptosishepatitis Bhepatocellular carcinomaproteinPTENvirus-Xprotein kinase Bprotein p53virus proteinanimal cell

Abstract 

PTEN gene, a novel tumor suppressor is frequently mutated or deleted in several malignancies including human hepatocellular carcinoma (HCC). We report previously that human hepatitis B virus-X (HBx) protein achieves protection from apoptotic cell death through-PI3K-Akt-Bad signaling that is p53-independent in liver cells (JBC; 276, 16969 (2000)). In this report, we demonstrated the PTEN effect on HBx induced anti-apoptotic signaling in Chang liver cells (CHL). Expression of PTEN in CHL cells downregulate HBx induced PI3K, Akt activities, Akt, Bad phosphorylations, decreased caspase 3 activity and protection from DNA fragmentations. PTEN suppression of CHL cell growth at G1 phase (JBC; 278,4057(2003)) in cell cycle analysis, which is overcome by HBx activated Akt/PKB further confirmed that same PI3K/Akt pathway is involved in cell survival and apoptosis by HBx and PTEN. PTEN suppression of HBx-mediated cell survival through PI3K pathway is specific, since PTEN does not suppress the effect of HBx on the protection from Fas-mediated apoptosis. Taken together, these findings demonstrate that PTEN potently modulate HBx-mediated signaling and is a viable target in therapeutic approaches to inhibit the formation of HCC caused by HBV infections.

ISSN 

0168-1702

Link 

http://dx.doi.org/10.1016/j.virusres.2006.06.010

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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