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Title 

The phosphotransferase system of Corynebacterium glutamicum: features of sugar transport and carbon regulation

Authors 

M W MoonS Y ParkSoo Keun ChoiJung-Kee Lee

Publisher 

Karger

Issue Date 

2007

Citation 

Journal of Molecular Microbiology and Biotechnology, vol. 12, no. 1, pp. 43-50

Keywords 

carbon catabolite repressioncorynebacterium glutamicumenzyme IIphosphotransferase systemsugar transportphosphotransferasecarbon metabolismbiological transportcarbon

Abstract 

In this review, we describe the phosphotransferase system (PTS) of Corynebacterium glutamicum and discuss genes for putative global carbon regulation associated with the PTS. C. glutamicum ATCC 13032 has PTS genes encoding the general phosphotransferases enzyme I, HPr and four enzyme II permeases, specific for glucose, fructose, sucrose and one yet unknown substrate. C. gluamicum has a peculiar sugar transport system involving fructose efflux after hydrolyzing sucrose transported via sucrose EII. Also, in addition to their primary PTS, fructose and glucose are each transported by a second transporter, glucose EII and a non-PTS permease, respectively. Interestingly, C. glutamicum does not show any preference for glucose, and thus co-metabolizes glucose with other sugars or organic acids. Studies on PTS-mediated sugar uptake and its related regulation in C. glutamicum are important because the production yield of lysine and cell growth are dependent on the PTS sugars used as substrates for fermentation. In many bacteria, the PTS is also involved in several regulatory processes. However, the detailed molecular mechanism of global carbon regulation associated with the PTS in this organism has not yet been revealed.

ISSN 

1464-1801

Link 

http://dx.doi.org/10.1159/000096458

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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