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Title 

The effect of erythrodiol-3-acetate on the expressions of matrix metalloproteinase-1 and type-1 procollagen caused by ultraviolet irradiated cultured primary old aged human skin fibroblasts

Authors 

H I MoonJoongku LeeJ H Chung

Publisher 

Elsevier

Issue Date 

2006

Citation 

Phytomedicine, vol. 13, no. 9, pp. 707-711

Keywords 

erythrodiol-3-acetatematrix metalloproteinase-1type-1 procollagenultra violeterythrodiol 3 acetateprocollagenagedhumanhuman cellprotein expression

Abstract 

Methanol and aqueous extracts of Styrax japonica used traditionally for the treatments of skin elastic materials were screened in vitro for the matrix metalloproteinase (MMP)-1 inhibitor actions. The methylene chloride soluble fraction of methanol extract from the stems of S. japonica showed significant MMP-1 inhibition in primary old aged human skin fibroblasts caused by ultraviolet (UV) irradiation. Main triterpenoids were isolated by repeated column chromatography. Among them, the triterpenoid erythrodiol-3-acetate reduced the expression of MMP-1 and induced the expression of type-1 procollagen at the protein levels in a dose-dependent manner caused by UV irradiated cultured old aged human skin fibroblasts. Taken together, our results suggest that erythrodiol-3-acetate plays an important role in the skin aging process caused by UV irradiation.

ISSN 

0944-7113

Link 

http://dx.doi.org/10.1016/j.phymed.2005.10.001

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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