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Title 

Talosins A and B: new isoflavonol glycosides with potent antifungal activity from Kitasatospora kifunensis MJM341: 1. taxonomy, fermentation, isolation, and biological activities

Authors 

T M YoonJ W KimJ G KimWon Gon KimJ W Suh

Publisher 

Nature Publishing Group

Issue Date 

2006

Citation 

Journal of Antibiotics, vol. 59, no. 10, pp. 633-639

Keywords 

6-deoxy-taloseantifungal agentgenisteinisoflavonol glycosidekitasatospora kifunensistalosin Atalosin Bamphotericin Bcarbohydrate derivativegenistein 4',7 di alpha levo 6 deoxytalopyranoside

Abstract 

In our screening program for new antifungal agents from microbial secondary metabolites, we isolated two new isoflavonol glycosides, genistein 7-α-L-6-deoxy-talopyranoside (talosin A) and genistein 4′,7-di-α-L-6-deoxy-talopyranoside (talosin B), from the culture broth of Kitasatospora kifunensis MJM341. The talosins exhibited strong antifungal activity against Candida albicans, Aspergillus niger and Cryptococcus neoformans with minimal inhibitory concentrations (MIC) in the range of 3-15 μg/ml while genistein and genistein-7-glucopyranoside did not show antifungal activity at 100 μg/ml. These talosins are the first isoflavonol glycosides with a 6-deoxy-talose sugar component and they may be useful as antifungal agents with low toxicity because of no visible cytotoxicity against the human hepatic HepG2 cell.

ISSN 

0021-8820

Link 

http://dx.doi.org/10.1038/ja.2006.84

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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