상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Ureidopyridazine derivatives as acyl-CoA:cholesterol acyltransferase inhibitors

Authors 

A GelainI BettinelliD BarloccoByoung-Mog KwonTae Sook JeongK R ImL LegnaniL Toma

Publisher 

?sterreichischer Apothekerverlag

Issue Date 

2006

Citation 

Scientia Pharmaceutica, vol. 74, no. 3, pp. 85-97

Keywords 

ACAT inhibitorshypercholesterolemiapyridazine derivativesureido derivativesacyl coenzyme Acholesterol acyltransferase inhibitorn (2,4 difluorophenyl) n' heptyl n'{4 [pyridazin 3 yl)thio]pentyl}urea derivativepyridazine derivativesulfone derivativeurea derivative

Abstract 

A series of N-(2,4-difluorophenyl)-N′-heptyl-N′-{4- [(substituted)-pyridazin-3-yl)thio]pentyl}urea derivatives having a phenyl ring at positions 5 and/or at position 6 of the heterocycle, as well as the corresponding sulfones, were synthesized. Their inhibitory activity against acyl-CoA:cholesterol acyltransferase (ACAT) was tested on the enzyme prepared from rat liver microsomes. Theoretical studies were performed to correlate their activity to their structural features.

ISSN 

0036-8709

Link 

http://dx.doi.org/10.3797/scipharm.2006.74.85

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


Files in This Item: SizeFormat
6710.pdf331KbAdobe PDF
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)