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Title 

Protein tyrosine phosphatase-1B inhibitory activity of isoprenylated flavonoids isolated from Erythrina mildbraedii

Authors 

Min Kyun NaJunPil JangD NjamenJ T MbaforZ T FomumBo Yeon KimWon Keun OhJong Seog Ahn

Publisher 

American Chemical Society

Issue Date 

2006

Citation 

Journal of Natural Products, vol. 69, no. 11, pp. 1572-1576

Keywords 

flavonoidprotein tyrosine phosphatase 1Bdrug activityerythrinaprotein analysisflavonoidsprotein-tyrosine-phosphatase

Abstract 

Inhibition of protein tyrosine phosphatase-1B (PTP1B) has been proposed as a therapy for treatment of type-2 diabetes and obesity. Bioassay-guided fractionation of an EtOAc-soluble extract of the root bark of Erythrina mildbraedii, using an in vitro PTP1B inhibitory assay, resulted in the isolation of three new isoprenylated flavonoids, abyssinone-IV-4′-O-methyl ether (2), 7-hydroxy-4′-methoxy-3′-(3-hydroxy-3-methyl-trans-but-1-enyl)- 5′-(3-methylbut-2-enyl)flavanone (3), and abyssinone-VI-4-O-methyl ether (6), along with six known flavonoids, abyssinone-V-4′-O-methyl ether (1), abyssinone-V (4), abyssinone-IV (5), sigmoidin E (7), 4′-hydroxy-5,7- dimethoxyisoflavone (8), and alpinumisoflavone (9). Compounds 1 and 2, 4-7, and 9 inhibited PTP1B activity, with IC50 values ranging from 14.8 ± 1.1 to 39.7 ± 2.5 μM. On the basis of the data obtained, flavanones and chalcones with isoprenyl groups may be considered as a new class of PTP1B inhibitors.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np0601861

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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