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Title 

Anticomplement activity of cycloartane glycosides from the rhizome of Cimicifuga foetida

 

승마에서 분리된 사이클로아탄 배당체의 항보체효과

Authors 

M QiuJung Hee KimHyeong Kyu LeeB S Min

Publisher 

Wiley-Blackwell

Issue Date 

2006

Citation 

Phytotherapy Research, vol. 20, no. 11, pp. 945-948

Keywords 

anticomplement activitycimicifuga foetidacimilactone Acycloartane-type triterpenoid9,19 cycloartane glycosideglycosidecimicifugarhizomeglycosides

Abstract 

A tetranor-cycloartane glycoside and two 9,19-cycloartane glycosides were isolated from the EtOAc-soluble fraction of the rhizome of Cimicifuga foetida. The structures of the compounds were determined to be cimilactone A (1), 25-O-acetylcimigenol 3-O-β-D-xylopyranoside (2) and cimigenol 3-0-α-L-arabinopyranoside (3), respectively, using spectroscopic analysis. The three compounds were examined for their anticomplement activity against the classical pathway of the complement system. Compound 1 showed significant anticomplement activity with an IC50 value of 28.6 μM, whereas compounds 2 and 3 were inactive.

ISSN 

0951-418X

Link 

http://dx.doi.org/10.1002/ptr.1982

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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