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Title 

Expression of vascular endothelial growth factor and angiogenesis in the diabetic frozen shoulder

 

diabetic frozen shoulder에서 VEGF의 발현과 angiogenesis

Authors 

J D RyuP A KirpalaniJ M KimKi Hoan NamC W HanS H Han

Publisher 

Elsevier

Issue Date 

2006

Citation 

Journal of Shoulder and Elbow Surgery, vol. 15, no. 6, pp. 679-685

Keywords 

angiogenesisfrozen shoulderprotein expressionneovascularization, pathologicshoulder jointvascular endothelial growth factor A

Abstract 

The purpose of this study was to investigate neovascularization and the expression of vascular endothelial growth factor (VEGF) in patients with diabetic frozen shoulders. Eleven patients with diabetic frozen shoulders underwent arthroscopic lysis of adhesions, and we observed the reported findings. VEGF expression was determined by immunohistochemistry and Western blot analysis, and the density of vessels was evaluated based on CD34 immunoreactivity by use of samples of the synovial tissue. For the control group, we took 5 samples of synovium from patients undergoing shoulder arthroscopy. The arthroscopic findings showed hyperemia of the synovial tissue in all cases of diabetic frozen shoulder. This synovium showed stronger immunostaining to VEGF (P = .010) and CD34 (P = .011) than the control synovial tissue. Western blot analysis also showed a stronger VEGF intensity than in the control group. We postulate that VEGF is synthesized and secreted in the synovium of diabetic frozen shoulders and VEGF may have some role in the pathogenesis and neovascularization of frozen shoulders in diabetic patients.

ISSN 

1058-2746

Link 

http://dx.doi.org/10.1016/j.jse.2006.01.002

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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