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Title 

Histopathological changes of testes and eyes by neutron irradiation with boron compounds in mice

 

마우스에 있어서 브론 복합물의 중성자 조사에 의한 정소와 눈의 조직병리학적 변화

Authors 

Y J KimWoon Kee YoonS Y RyuK J ChunH Y SonS W Cho

Publisher 

The Korean Society of Veterinary Science

Issue Date 

2006

Citation 

Journal of Veterinary Science, vol. 7, no. 1, pp. 19-23

Keywords 

boroneyehistopathologyneutron irradiationtestesboronophenylalaninolC57BL mousemouseneutronneutron capture therapy

Abstract 

This study was performed to investigate the biological effects of boron neutron capture therapy (BNCT) on the testes and eyes in mice using HANARO Nuclear Reactor, Korea Atomic Energy Research Institute. BNCT relies on the high capacity of 10B in capturing thermal neutrons. Sodium borocaptate (BSH, 75 ppm, iv) and boronophenylalanine (BPA, 750 ppm, ip) have been used as the boron delivery agents. Mice were irradiated with neutron (flux: 1.036739E +09, Fluence 9.600200E+12) by lying flat pose for 30 (10 Gy) or 100 min (33 Gy) with or without boron carrier treatment. In 45 days of irradiation, histopathological changes of the testes and eyes were examined. Thirty-three Gy neutron irradiation for 100 min induced testicular atrophy in which some of seminiferous tubules showed complete depletion of spermatogenic germ cells. Lens epithelial cells and lens fiber were swollen and showed granular changes in an exposure time dependent manner. However, boron carrier treatment had no significant effect on the lesions. These results suggest that the examination of histopathological changes of lens and testis can be used as "biological dosimeters" for gauging radiation responses and the HANARO Nuclear Reactor has sufficient capacities for the BNCT.

URI 

https://doi.org/10.4142/jvs.2006.7.1.19

ISSN 

1229-845X

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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