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Title 

Inhibitory effect of Thujae orientalis semen extract on pancreatic lipase activity

 

백자인 추출물에 의한 pancreatic lipase의 저해 효과

Authors 

Min-Soo KimBo Yeon KimChan Sun ParkByung Dae YoonS C AhnWon Keun OhJong Seog Ahn

Publisher 

Korean Society of Life Science

Issue Date 

2006

Citation 

Korean Journal of Life Sciences, vol. 16, no. 2, pp. 328-332

Keywords 

pancreatic lipase inhibitorthujae orientalis

Abstract 

The possible presence of inhibitors of pancreatic lipase (tricaylglycerol acylhydrolase EC 3.1.1.3) was screened from Korean traditional edible or medicinal herbs. Among tested herbs, Arecae pericarpium, Mucunae Caulis, Rhus javanica, Thujae orientalis were shown to have strong inhibitory effect against pancreatic lipase. Thujae orientalis was finally selected as a candidate for pancreatic lipase inhibitor. The extract of Thujae orientalis was showed selective inhibition on porcine pancreatic lipase activity. Active inhibitors, TF-1, TF-2, TF-3, were purified from an extract of Thujae orientalis, using chloroform extraction, followed by successive chromatography in silica gel and LH-20 and high performance liquid chromatography (HPLC). The IC50 values of TF-1, TF-2, TF-3 and orlistat were 44.7, 98.7, 46.1 and 27.6 ㎍/ml, respectively. And also the TF-2 and orlistat were shown to be inhibitory effect on the differentiation of preadipocyte NIH-3T3 L1 cells at a concentration of 10 ㎍/ml.

ISSN 

1225-9918

Link 

http://dx.doi.org/10.5352/JLS.2006.16.2.328

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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