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Title 

Cytotoxic and ACAT-inhibitory sesquiterpene lactones from the root of lxeris dentata forma albiflora

 

세스큐터핀의 세포독성

Authors 

E M AhnM H BangM C SongM H ParkH Y KimByoung-Mog KwonN I Baek

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2006

Citation 

Archives of Pharmacal Research, vol. 29, no. 11, pp. 937-941

Keywords 

A549ACATHT29Ixeris dentata forma albiflorasesquiterpene lactonelactonesesquiterpenelactonessesquiterpenes

Abstract 

Ixeris dentata forma albiflora was extracted with 80% aqueous MeOH, and the concentrated extract was partitioned with EtOAc, n-BuOH and H2O. Eight sesquiterpenes were isolated through repeated silica gel and octadecyl silica gel (C18, ODS) column chromatography of the EtOAc and n-BuOH fractions. Physicochemical analysis using NMR, MS and IR revealed the chemical structures of the sesquiterpenes, which were zaluzanin (1), 9a-hydroxyguaian- 4(15),10(14),11(13)-triene-6,12-olide (2), 3β-O-β-D-glucopyranosyl- 8β-hydroxyguaian-4(15),10(14)-diene-6,12-olide (3), 3-O-β-D- glucopyranosyl-8β-hydroxyguauan-10(14)-ene-6,12-olide (4), ixerin M (5), glucozaluzanin C (6), crepiside I (7), and ixerin D (8). This is the first time that these sesquiterpene lactones have been isolated from this plant. Compounds 1, 2 and 7 revealed relatively high cytotoxicities on human colon carcinoma cell and lung adenocarcinoma cell, while compounds 5 and 7 showed acyl-CoA: cholesterol acyltransferase (ACAT) inhibitory activity.

ISSN 

0253-6269

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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