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Title 

Angelan isolated from Angelica gigas Nakai induces dendritic cell maturation through toll-like receptor 4

Authors 

Jee Youn KimYeo Dae YoonJi Mi AhnJong Soon KangSong Kyu ParkKiho LeeK B SongHwan Mook KimSang Bae Han

Publisher 

Elsevier

Issue Date 

2007

Citation 

International Immunopharmacology, vol. 7, no. 1, pp. 78-87

Keywords 

angelanangelica gigas Nakaidendritic cellspolysaccharidestoll like receptor 4angelica gigasanimal cellcell maturationdendritic cellmelanoma cell

Abstract 

During the evolution of neoplastic diseases, dendritic cell (DC) functions are usually attenuated, and this presents a problem to DC-based immunotherapies against cancer. Here, we investigated the effects of angelan, an acidic polysaccharide isolated from Angelica gigas Nakai, on DC maturation. Angelan efficiently increased the maturation of tlr4+/+ DCs from C57BL/6 and C3H/HeN mice, but not tlr4-/- DCs from C3H/HeJ mice. Phenotypic maturation was confirmed by the elevated expressions of CD80, CD86, and MHC-class II molecules, and functional maturation by increased IL-12 production, enhanced allogenic T cell stimulation, and decreased endocytosis. Angelan was found to activate ERK and NF-κB, which are signaling molecules down-stream of toll-like receptor-4 (TLR4) receptors. Angelan-treated mature DC more effectively inhibited B16F10 tumor growth than immature DCs in syngenic murine tumor model. These results indicate that angelan induces DC maturation via TLR4 signaling pathways and suggest the possible use of angelan in DC-based immunotherapies.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2006.08.017

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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