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Title 

Inhibition of diacylglycerol acyltransferase by alkamides isolated from the fruits of Piper longum and Piper nigrum

Authors 

Seung Woong LeeMun Chual RhoHye Ran ParkJung-Ho ChoiJi Yun KangJung Won LeeK KimHyun Sun LeeYoung Kook Kim

Publisher 

American Chemical Society

Issue Date 

2006

Citation 

Journal of Agricultural and Food Chemistry, vol. 54, no. 26, pp. 9759-9763

Keywords 

alkamidesdiacylglycerol acyltransferase (DGAT)piper longumpiper nigrumdiacylglycerol acyltransferasefruitpiperaceaediacylglycerol o-acyltransferasepiper

Abstract 

Pharmacological inhibition of acyl CoA:diacylglycerol acyltransferase (DGAT, EC 2.3.1.20) has emerged as a potential therapy for the treatment of obesity and type 2 diabetes. Bioassay-guided isolation of CHCl3 extracts of the fruits of Piper longum and Piper nigum (Piperaceae), using an in vitro DGAT inhibitory assay, lead to isolation of a new alkamide named (2E,4Z,8E)-N-[9-(3,4-methylenedioxyphenyl)-2,4,8-nonatrienoyl]piperidine (2), together with four known alkamides: retrofractamide C (1), pipernonaline (3), piperrolein B (4), and dehydropipernonaline (5). Compounds 2-5 inhibited DGAT with IC50 values of 29.8 (2), 37.2 (3), 20.1 (4), and 21.2 (5) μM, respectively, but the IC50 value for 1 was more than 900 μM. This finding indicates that compounds possessing piperidine groups (2-5) can be potential DGAT inhibitors.

ISSN 

0021-8561

Link 

http://dx.doi.org/10.1021/jf061402e

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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