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Title 

Bionectins A-C, epidithiodioxopiperazines with anti-MRSA activity, from Bionectra byssicola F120

Authors 

C J ZhengChang-Jin KimKyung Sook BaeY H KimWon Gon Kim

Publisher 

American Chemical Society

Issue Date 

2006

Citation 

Journal of Natural Products, vol. 69, no. 12, pp. 1816-1819

Keywords 

antiinfective agentbionectin abionectin bbionectin cepidithiodioxopiperazine derivativepiperazinedionevancomycinverticillin dantibacterial activitybionectra byssicola

Abstract 

Three new epidithiodioxopiperazine compounds, bionectins A (1), B (2), and C (3), along with a known compound, verticillin D (4), have been isolated from the mycelium of liquid fermentation cultures of the fungus Bionectra byssicola Fl 20. The structures of compounds 1-3 were assigned on the basis of MS and NMR data. Compounds 1 and 2 incorporate a dioxopiperazine moiety with a disulfide bridge in their molecules, while 3 contains a dioxopiperazine ring with two methylsulfanyl groups. Compounds 1 and 2 exhibited antibacterial activity against S. aureus including methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), with MIC values of 10-30, μg/mL, while 3 showed no antibacterial activity even at 100 μg/mL.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np060348t

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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