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Title 

A proteomic analysis of the effect of MAPK pathway activation on L-glutamate-induced neuronal cell death

 

HT22 세포주에서의 glutamate 유도 세포사멸 과정중의 MAPK pathway 효과

Authors 

Sunghyun KangE Y KimYoung Jae BahnJin Woong ChungDo Hee LeeSung Goo ParkTae-Sung YoonByoung Chul ParkKwang-Hee Bae

Publisher 

Springer Verlag (Germany)

Issue Date 

2007

Citation 

Cellular and Molecular Biology Letters, vol. 12, no. 1, pp. 139-147

Keywords 

apoptosisHT22MAPKoxidative stressreactive oxygen speciesU0126calreticulinchaperonecytoskeleton proteinelongation factor 2

Abstract 

Oxidative stress has been implicated in the pathogenesis of neuronal degenerative diseases. It is also widely known that oxidative stress induces mitogen-activated protein kinase (MAPK) signaling cascades. In this study, we used proteomic analysis to investigate the role of the MAPK pathway in oxidative stress-induced neuronal cell death. The results demonstrated that several proteins, including eukaryotic translation elongation factor 2 (eEF2) and enolase I, showed a differential expression pattern during the neuronal cell death process, and this was MAPK pathway dependent. Several chaperone and cytoskeletal proteins including heat shock protein 70, calreticulin, vimentin, prolyl 4-hydroxylase β polypeptide, and transgelin 2 were up- or down-regulated, despite their expressions not depending on the MAPK pathway. These findings strongly suggest that the expressions of proteins which play protective roles are independent of the MAPK pathway. On the other hand, eEF2 and enolase I may be the downstream targets of the MAPK pathway.

ISSN 

1425-8153

Link 

http://dx.doi.org/10.2478/s11658-006-0057-8

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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