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Title 

Stimulation of cell growth by erythropoietin in RAW264.7 cells: association with AP-1 activation

Authors 

S R SeongJ W LeeY K LeeT I KimD J SonD C MoonY W YunDo Young YoonJ T Hong

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2006

Citation 

Archives of Pharmacal Research, vol. 29, no. 3, pp. 218-223

Keywords 

AP-1cell growthEPOerythropoietintranscription factor AP 1cell linecell proliferationcell shapecell strainPC12 cells

Abstract 

Erythropoietin (EPO), a hematopoietic factor, is required for normal erythrocyte developments, but it has been demonstrated to have many other functions, and its receptor is localized in other tissues. In the present study, we investigated whether EPO can promote other cell proliferation and possible molecular mechanisms. EPO restored the inhibition of the RAW264.7 and PC12 cell growth by fetal bovine serum (FBS) withdrawal in a dose dependent manner, but not that of other cell types tested. The restoring effect of EPO was completed when the RAW264.7 cells were cultured in the medium containing as low as 3% of FBS, and 10 U/mL EPO could replace FBS. The restoring effect of EPO in the RAW264.7 cells was associated with the increased of c-Fos and c-Jun expression as well as AP-1 activation. These data demonstrate that EPO can stimulate RAW264. 7 cell as well as PC12 cell growth even when the cells were cultured without FBS or in the presence of small amounts of FBS in the medium, and this stimulating effect is associated with the activation of AP-1 transcription factor.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/BF02969397

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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