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Title 

N-Benzylbenzamides: A new class of potent tyrosinase inhibitors

Authors 

S J ChoJ S RohW S SunS H KimK D Park

Publisher 

Elsevier

Issue Date 

2006

Citation 

Bioorganic & Medicinal Chemistry Letters, vol. 16, no. 10, pp. 2682-2684

Keywords 

4-Substituted resorcinolN-BenzylbenzamidesSARtyrosinase inhibitorbenzamide derivativeenzyme inhibitorlevodopamonophenol monooxygenasemonophenol monooxygenase inhibitorunclassified drug

Abstract 

A series of potent inhibitors of tyrosinase and their structure-activity relationships are described. N-Benzylbenzamide derivatives (1-21) with hydroxyl(s) were synthesized and tested for their tyrosinase inhibitory activity. With this series, compound 15 provided a potent tyrosinase inhibition: it effectively inhibited the oxidation of l-DOPA catalyzed by mushroom tyrosinase with an IC50 of 2.2 μM.

ISSN 

0960-894X

Link 

http://dx.doi.org/10.1016/j.bmcl.2006.02.018

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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