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Title 

Recombination activating genes (RAG) in lymphoma development

Authors 

B B HainesChun Jeih RyuJ Chen

Publisher 

Landes Bioscience

Issue Date 

2006

Citation 

Cell Cycle, vol. 5, no. 9, pp. 913-916

Keywords 

double strand DNA breaklymphomagenesisp53recombination activating gene (RAG)protein RAGDNA recombinationlymphomaoncogenegenes, bcl-2genes, p53

Abstract 

The recombination activating genes (RAG) play a central role in the generation of a diverse immune repertoire by mediating DNA recombination events at antigen receptor loci in developing B and T lymphocytes. However, inappropriate RAG activity throughout the genome has been implicated in a large variety of human and mouse lymphomas. Mechanisms by which RAG can provoke or perpetuate lymphoma include deregulation of certain genes by translocation to antigen receptor regulatory regions, the formation of chimeric oncogenes, inactivation of tumor suppressor or micro-RNA loci, or activation of oncogenes. Here we present the T cell receptor enhancer (Eβ) deficient mouse as a tractable in vivo model system to study the role of RAG activity in the context of lymphoma development, and contrast our system with those of others. We posit a general hypothesis that virtually any mutation that impairs early lymphocyte development at stages when RAG is expressed can constitute a pro-carcinogenic event. Our model system provides a means to assess the roles of RAG activity in human lymphoid malignancies.

ISSN 

1538-4101

Link 

http://dx.doi.org/10.4161/cc.5.9.2732

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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