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Title 

Curcumin-induced histone hypoacetylation enhances caspase-3-dependent glioma cell death and neurogenesis of neural progenitor cells

Authors 

S K KangS H ChaHyo Kon Chun

Publisher 

Mary Ann Liebert

Issue Date 

2006

Citation 

Stem Cells and Development, vol. 15, no. 2, pp. 165-174

Keywords 

caspase 3curcuminhistonehistone acetyltransferasehistone acetyltransferase inhibitorhistone H3histone H4cell deathcell migrationglioma cell

Abstract 

Acetylation of histones and nonhistone proteins is an important post-translational modification involved in the regulation of gene expression in mammalian cells. Dysfunction of histone acetyltransferase (HAT) is often associated with the manifestation of several diseases. In this report, HATs are new targets for the development of therapeutics. Our studies first proved that curcumin induces histone hypoacetylation in brain cancer cells and finally induces apoptotic cell death through a (PARP)- and caspase 3-mediated manner. In addition, curcumin induces recontrolling of neural stem cell fates. It induces effective neurogenesis, synaptogenesis, and migration of neural progenitor cells in vitro in brain-derived adult neural stem cells. We also confirmed the neurogenic effect of curcumin in our in vivo experiments. Curcumin actively suppressed differentiation in astrocytes while promoting differentiation into the neurons associated with decrease of histone H3 and H4 acetylation. We suggest that histone hypoacetylation plays an important role in determine stem cell fate through controlling the simultaneous expression of many genes. Thus, the present finding that curcumin, a nontoxic dietary compound, is a histone acetyltransferase inhibitor would supply a new window to understand further the molecular mechanism of histone acetylase inhibitors (HAI) in cancer and neural stem cells and provide a new target molecule for treating central nervous system disorders.

ISSN 

1547-3287

Link 

http://dx.doi.org/10.1089/scd.2006.15.165

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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