상세 정보

underline
Metadata Downloads : dc(xml) or Excel
Cited 0 time in scopus ci

Title 

Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae

Authors 

C J ZhengMi Jin SohnWon Gon Kim

Publisher 

Nature Publishing Group

Issue Date 

2006

Citation 

Journal of Antibiotics, vol. 59, no. 12, pp. 808-812

Keywords 

atromentinenoyl-ACP reductaseFabKleucomelonestreptococcus pneumoniaeterphenylenoyl acyl carrier protein reductase (NADPH)enzyme inhibitorenoyl-(Acyl-Carrier-Protein) reductase (NADH)

Abstract 

Two potent inhibitors of FabK, the enoyl-acyl carrier protein (ACP) reductase of Streptococcus pneumoniae, were isolated from the solid state fermentation of an unidentified fungus F010248. Their structures were identified to be atromentin and leucomelone by various spectral analysis. Atromentin and leucomelone inhibited the FabK with IC50 values of 0.24 and 1.57 μM, respectively, while did not inhibit FabI, the enoyl-ACP reductase of either Escherichia coli or Staphylococcus aureus, even at 200 μM. Atromentin and leucomelone are the first inhibitors specific to the enoyl-ACP reductase (FabK) of Streptococcus pneumoniae.

ISSN 

0021-8820

Link 

http://dx.doi.org/10.1038/ja.2006.108

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


There are no files associated with this item.
qrcode

FusionCharts.
DSpace Software Coptright(c) 2010 MIT and Hewleft-Packard  /  KRIBB-REPOSITORY ( Email:jakim@kribb.re.kr)