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Title 

2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induces the apoptosis of human hepatoma HepG2 cells

 

2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid 처리에 의한 인간 간암세포주 HepG2의 apoptosis 유도

Authors 

K H YooJ M LeeJ Hwang-BoM C SongH J YangN I BaekS H KimD K KimByoung-Mog KwonM H ParkI S Chung

Publisher 

Korean Society for Applied Biological Chemisty

Issue Date 

2006

Citation 

Journal of Korean Society for Applied Biological Chemistry, vol. 49, no. 4, pp. 270-275

Keywords 

23-trihydroxyrus-12-ene-28-oic acidHepG2apoptosiscytotoxicity

Abstract 

2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid was isolated from Trapa pseudoincisa S. et Z. It has a common structure of pentacyclic triterpenes and belongs to the amyrin ursolic acid group. The cytotoxic effect of this compound was investigated in human hepatoma cell line HepG2. 2β, 3α, 23- trihydroxyrus-12-ene-28-oic acid showed dose-dependent cytotoxicity in HepG2 cells. Confocal microscopy data showed that green fluorescence was increased in 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid treated-HepG2 cells in a time-dependent manner. 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid also increased the sub-G1 cell population of HepG2 cells as well as ladder-like DNA fragmentation. Taken together, our results indicate that 2β, 3α, 23-trihydroxyrus-12-ene-28-oic acid induced apoptosis in HepG2 cells.

ISSN 

1738-2203

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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