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Title 

Embellistatin, a microtubule polymerization inhibitor, inhibits angiogenesis both in vitro and in vivo

Authors 

H J JungJ S ShimH B LeeChang-Jin KimT KuwanoM OnoH J Kwon

Publisher 

Elsevier

Issue Date 

2007

Citation 

Biochemical and Biophysical Research Communications, vol. 353, no. 2, pp. 376-380

Keywords 

anti-angiogenic agentanti-microtubule agentcell cycle arrestembellisia chlamydosporaembellistatinangiogenesis inhibitorbasic fibroblast growth factorcyclin dependent kinase inhibitor 1ketone derivativeangiogenesis

Abstract 

The efficient inhibition of angiogenesis is considered as a promising strategy for the treatment of angiogenesis-related diseases including cancer. Herein, we report that embellistatin, a bicyclic ketone compound known as a microtubule polymerization inhibitor, exhibits anti-angiogenic activity. Embellistatin inhibited in vitro angiogenesis of bovine aortic endothelial cells (BAECs) such as bFGF-induced invasion and tube formation as well as bFGF-induced mouse corneal angiogenesis in vivo. Notably, embellistatin exhibited stronger inhibition activity for the growth of BAECs than that of normal and cancer cell lines. Cell cycle analysis revealed that the compound arrests cell cycle at G2/M phase, which is associated with the increased expression of p21WAF1 and p53 partly. These results demonstrate that embellistatin may serve the basis for the development of new anti-angiogenic agents.

ISSN 

0006-291X

Link 

http://dx.doi.org/10.1016/j.bbrc.2006.12.026

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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