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Title 

Triterpenoid saponin from Viola hondoensis W. Becker et H Boss. and their effect on MMP-1 and type I procollagen expression

Authors 

H I MoonJ H ChungJoongku LeeO P Zee

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2004

Citation 

Archives of Pharmacal Research, vol. 27, no. 7, pp. 730-733

Keywords 

MMP1 inhibitortriterpenoid saponinviola hondoensisviolaceaecatechincollagen type 1drug derivativeepigallocatechin gallateinterstitial collagenasesaponin

Abstract 

Bioassay-guided fractionation has led to the isolation of triterpenoid saponins such as Acutoside A (3-O-[O-β-D-glucopyranosyl-(1→2)-O- β-D-glucopyranosyl] oleanolic acid) from the whole plants of Viola hondoensis. Among them, Saponin 1 exhibited potent inhibitory activity against matrix metalloproteinase (MMP)-1, and prevented the UV-induced changes in the MMP-1 expression. In addition, compound was isolated from this plant for the first time.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/BF02980140

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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