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Title 

Equol inhibits nitric oxide production and inducible nitric oxide synthase gene expression through down-regulating the activation of Akt

Authors 

Jong Soon KangYeo Dae YoonMi Hwa HanSang Bae HanKiho LeeSong Kyu ParkHwan Mook Kim

Publisher 

Elsevier

Issue Date 

2007

Citation 

International Immunopharmacology, vol. 7, no. 4, pp. 491-499

Keywords 

Aktequolinducible nitric oxide synthaseNF-κBnitric oxidegene expression regulationdown-regulationgene expression regulation, enzymologic

Abstract 

In the present study, we report the inhibitory effect of equol on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) gene expression in murine macrophages. In vivo administration of equol (i.p.) attenuated NO production by peritoneal adherent cells isolated from lipopolysaccharide (LPS)-treated mice. Equol dose-dependently inhibited the LPS-induced production of NO in isolated peritoneal adherent cells and RAW 264.7 cells. The mRNA expression of iNOS was also blocked by equol in LPS-stimulated RAW 264.7 cells. Further study demonstrated that the LPS-induced activation of Akt was suppressed by equol in RAW 264.7 cells while the activation of ERK, SAPK/JNK and p38 MAP kinase was not affected. Equol also blocked LPS-induced NF-κB activation. Moreover, the LPS-induced NO production and NF-κB activation was inhibited by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase/Akt pathway, in RAW 264.7 cells. These results suggest that equol might inhibit NO production and iNOS gene expression, at least in part, by blocking Akt activation and subsequent down-regulation of NF-κB activity.

ISSN 

1567-5769

Link 

http://dx.doi.org/10.1016/j.intimp.2006.12.004

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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