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Title 

ACAT inhibition of alkamides identified in the fruits of Piper nigrum

Authors 

Mun Chual RhoSeung Woong LeeHye Ran ParkJung Ho ChoiJi Yun KangK KimHyun Sun LeeYoung Kook Kim

Publisher 

Elsevier

Issue Date 

2007

Citation 

Phytochemistry, vol. 68, no. 6, pp. 899-903

Keywords 

Acyl CoAcholesterol acyltransferase (ACAT)alkamidesatherosclerosiscellular cholesterol esterificationHepG2 cellspiper nigum L.piperaceaedehydropipernonalinepiperidine derivative

Abstract 

In this study, via a bioactivity-guided fractionation of MeOH extracts of the fruits of Piper nigrum, alkamide (5) and five previously-identified alkamides were isolated. Their structures were elucidated via spectroscopic analysis (1H, 13C NMR and ESI-MS), as follows: retrofractamide A (1), pipercide (2), piperchabamide D (3), pellitorin (4), dehydroretrofractamide C (5) and dehydropipernonaline (6). The IC50 values determined for the compounds were 24.5 (1), 3.7 (2), 13.5 (3), 40.5 (4), 60 (5) and 90 μM (6), according to the results of an ACAT enzyme assay system using rat liver microsomes. These compounds all inhibited cholesterol esterification in HepG2 cells.

ISSN 

0031-9422

Link 

http://dx.doi.org/10.1016/j.phytochem.2006.11.025

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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