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Title 

Cytotoxic 6-alkylsalicylic acids from the endophytic Streptomyces laceyi

Authors 

N KimJ C ShinWon Cheol KimB Y HwangB S KimYoung-Soo HongD Lee

Publisher 

Nature Publishing Group

Issue Date 

2006

Citation 

Journal of Antibiotics, vol. 59, no. 12, pp. 797-800

Keywords 

alkysalicylic acidcytotoxicstreptomyces6 salicylic acidsalaceyin asalaceyin bsalicylic acidcytotoxicitysalicylic acids

Abstract 

Two new 6-alkylsalicylic acids, salaceyins A and B were isolated by bioassay-guided fractionation from the culture of the endophytic Streptomyces laceyi MS53 and their structures were determined on the basis of spectroscopic data. Salaceyins A and B exhibited modest cytotoxicity against a human breast cancer cell line (SKBR3) with IC50 values of 3.0 and 5.5 μg/ml, respectively.

ISSN 

0021-8820

Link 

http://dx.doi.org/10.1038/ja.2006.105

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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