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Title 

Glabrol, an acyl-coenzyme A: Cholesterol acyltransferase inhibitor from licorice roots

Authors 

Jung Ho ChoiMun Chual RhoSeung Woong LeeO E KwonHye Ran ParkJi Yun KangS H LeeHyun Sun LeeK H BaeYoung Kook Kim

Publisher 

Elsevier

Issue Date 

2007

Citation 

Journal of Ethnopharmacology, vol. 110, no. 3, pp. 563-566

Keywords 

Acyl-CoAcholesterol acyltransferaseatherosclerosishypocholesterolemialicoricealcoholcholesterolcholesterol acyltransferase inhibitorcholesterol ester

Abstract 

Acyl-coenzyme A: cholesterol acyltransferase (ACAT) esterifies free cholesterol in the liver and the intestine. It has relations with production of lipoproteins and accumulation of cholesteryl esters of the atheroma. Therefore, ACAT inhibitors may act as antihypercholesterolemic and antiatherosclerotic agents. One isoprenyl flavonoid was isolated from ethanol extract of licorice roots. On the basis of spectral evidences, the compound was identified as glabrol (1). Compound 1 inhibited rat liver microsomal ACAT activity with an IC50 value of 24.6 μM and decreased cholesteryl ester formation with an IC50 value of 26.0 μM in HepG2 cells. In addition, 1 showed a non-competitive type of inhibition against ACAT.

ISSN 

0378-8741

Link 

http://dx.doi.org/10.1016/j.jep.2006.10.012

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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