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Title 

(Aryloxyacetylamino)benzoic acid analogues: a new class of hypoxia-inducible factor-1 inhibitors

Authors 

Kyeong LeeJ H LeeS K BoovanahalliY JinM LeeX JinJin Hwan KimYoung-Soo HongJung Joon Lee

Publisher 

American Chemical Society

Issue Date 

2007

Citation 

Journal of Medicinal Chemistry, vol. 50, no. 7, pp. 1675-1684

Keywords 

3 [2 (4 adamantan 1 ylphenoxy)acetylamino] 4 hydroxybenzoic acid3 [2 (4 adamantan 1 ylphenoxy)acetylamino] 4 hydroxybenzoic acid methyl ester4 [2 (4 adamantan 1 ylphenoxy)acetylamino]benzoic acidbenzoic acid derivativehypoxia inducible factor 1hypoxia inducible factor 1 inhibitorprotein inhibitorantineoplastic activitycancer cell culturecarcinoma cell

Abstract 

Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1α protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.

ISSN 

0022-2623

Link 

http://dx.doi.org/10.1021/jm0610292

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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