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Title 

A facile synthesis of 2-acyl and 2-alkylaminobenzimidazoles for 5-lipoxygenase inhibitors

Authors 

Jin Ha LeeMi Hyun AhnE H ChoiH Y Park ChooG Han

Publisher 

Elsevier

Issue Date 

2006

Citation 

Heterocycles, vol. 70, no. 1, pp. 571-580

Abstract 

2-Acylaminobenzimidazoles (2a-r) have been synthesized from o-phenylenediamines (4) with benzoylcarbonimidodithioic acid dimethyl ester (5a) or isobutyrylcarbonimidodithioic acid dimethyl ester (5b) in good yield. 2-Alkylaminobenzimidazoles could be prepared by the reaction of o-Phenylenediamines (4a, b) with benzyl isothiocyanate in moderate yields 8a, b or the reaction of 2-chlorobenzimidazole (9) with benzylamines (10a, b) in moderate yield 11a, b. Finally, the carbamate derivative of 2-aminobenzimidazole (13) was prepared by the reaction with pseudourea (12) in low yield. Most of the prepared analogues were evaluated in leukotriene inhibition assay and it found that benzamide derivatives (2a-i) are quite active among others.

ISSN 

0385-5414

Link 

http://dx.doi.org/10.1002/chin.200723117

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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