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Title 

Farnesyl protein transferase and tumor cell growth inhibitory activities of lipiferolide isolated from Liriodendron tulipifera

Authors 

M K MoonH M OhByoung-Mog KwonN I BaekS H KimJ S KimD K Kim

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2007

Citation 

Archives of Pharmacal Research, vol. 30, no. 3, pp. 299-302

Keywords 

cell growth inhibitory activityFPTaselipiferolideliriodendron tulipiferap21(ras) farnesyl protein transferasep21(ras) farnesyl-protein transferasetransferasecell strain HL 60cell strain K 562liriodendron

Abstract 

The methanolic extract of the leaves of Liriodendron tulipifera was found to show inhibitory activity towards farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of lipiferolide, an inhibitor of FPTase. This compound inhibited the FPTase activity in a dose-dependent manner, and showed cell growth inhibitory activity against several tumor cells.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/BF02977609

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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