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Title 

Genomic sequence variability of the prion gene (PRNP) in Korean cattle

Authors 

Sang-Haeng ChoiSung-Hwa ChaeHan-Ho ChoiJ S KimB R KangJ S YeoI ChoiY S LeeY H ChoyHong-Seog Park

Publisher 

The Asian-australasian Association of Animal

Issue Date 

2007

Citation 

Asian-Australasian Journal of Animal Sciences, vol. 20, no. 5, pp. 653-660

Keywords 

BSEindelKorean cattlePRNPSNP

Abstract 

In this study, we have investigated sequence variants in the PRNP gene of 20 individuals belonging to the Korean cattle, and have analyzed and compared genetic features between varieties of other cattle breeds. of the 73 sequence variants identified in Korean cattle, 27 were identified for the first time in this study, whereas 46 of these polymorphisms had previously been isolated. We discovered a 2.6 kb SNP hot spot region localized on the putative promoter region of the PRNP gene. Furthermore, the copy numbers of the octapeptide repeat (24 bp indel) which is detected on the coding sequence (CDS) of the PRNP exhibited a completely homozygous 6/6 genotype which is dominant in other cattle breeds. We also characterized a new 19 bp/10 bp allele located on the putative promoter region of the PRNP gene, which represented 0.71 in allele frequency. To the best of our knowledge, this report is the first to address polymorphisms of the PRNP gene structure in Korean cattle in which BSE has yet to be discovered. Therefore, our findings may prove useful with regard to our current understanding of allelic diversity in bovine species, and may also provide new insights into the genetic factors associated with susceptibility or resistance to BSE.

URI 

https://doi.org/10.5713/ajas.2007.653

ISSN 

1011-2367

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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