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Title 

Inhibitory effect of obovatal on the migration and invasion of HT1080 cells via the inhibition of MMP-2

Authors 

Su-Kyung LeeHyo Kon ChunJ Y YangDong Cho HanKwang Hee SonByoung-Mog Kwon

Publisher 

Elsevier

Issue Date 

2007

Citation 

Bioorganic & Medicinal Chemistry, vol. 15, no. 12, pp. 4085-4090

Keywords 

cell invasioncell migrationmagnolia obovata THUNBmatrix metalloproteinase-2 (MMP-2)obovatalcancer celldrug effectenzyme inhibition

Abstract 

Because the activation of matrix metalloproteinases (MMP) is a key factor in the metastatic process, compounds with the ability to inhibit MMP activity have a potential in the treatment of tumor. From the examination of 2000 plant extracts, obovatal isolated from the extract of the leaves of Magnolia obovata THUNB was a potent inhibitor of MMP-2 enzyme in vitro. In human fibrosarcoma cells (HT1080) activated with MMP-2, obovatal inhibited MMP-2 enzyme activity and expression. In addition, the compound blocked migration and invasion of the cells. This study demonstrates that obovatal exerts its anticancer effects through blocking migration and invasion by inhibition of MMP-2 expression and activity, and also will be a good lead molecule for the development of anti-tumor drug.

ISSN 

0968-0896

Link 

http://dx.doi.org/10.1016/j.bmc.2007.03.081

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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