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Title 

Differential antiviral activity of benzastatin C and its dechlorinated derivative from Streptomyces nitrosporeus

Authors 

J G LeeIck Dong YooWon Gon Kim

Publisher 

Pharmaceutical Society of Japan

Issue Date 

2007

Citation 

Biological & Pharmaceutical Bulletin, vol. 30, no. 4, pp. 795-797

Keywords 

antiviral activitybenzastatin Cchloro-tetrahydroquinolonestreptomyces nitrosporeusdrug derivativequinoline derived antiinfective agentanimal cellcontrolled studydechlorination

Abstract 

Benzastatin C, a 3-chloro-tetrahydroquinolone alkaloid from Streptomyces nitrosporeus, showed antiviral activity in a dose-dependant manner with EC 50 values of 1.92, 0.53, and 1.99 μg/ml against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and vesicular stomatitis virus (VSV), respectively. In contrast, benzastatin D, the corresponding dechlorinated derivative, did not exhibit any antiviral activity. These results indicate that the antiviral activity of benzastatin C is mediated, in part, due to the chlorine moiety in its molecular structure.

ISSN 

0918-6158

Link 

http://dx.doi.org/10.1248/bpb.30.795

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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