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Title 

Lignans from the fruits of Cornus kousa Burg. and their cytotoxic effects on human cancer cell lines

Authors 

D Y LeeM C SongK H YooM H BangI S ChungS H KimD K KimByoung-Mog KwonTae Sook JeongM H ParkN I Baek

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2007

Citation 

Archives of Pharmacal Research, vol. 30, no. 4, pp. 402-407

Keywords 

cornus kousacytotoxicityhuman colon carcinoma (HCT-116)human hepatocellular carcinoma (HepG2)lignanMTT assaycornusfruithumantumor cell line

Abstract 

The fruits of Cornus kousa Burg. were extracted with 80% aqueous MeOH, and the concentrated extract partitioned with EtOAc, n-BuOH and H2O. Six lignans were isolated from the EtOAc fraction through repeated silica gel, ODS and Sephadex LH-20 column chromatographies. From the physico-chemical data, including NMR, MS and IR, the chemical structures of the compounds were determined to be (+)-pinoresinol (1), (-)-balanophonin (2), (+)-laricresinol (3), erythro-guaiacylglycerol-β-coniferyl aldehyde ether (4), threo-guaiacylglycerol-β-coniferyl aldehyde ether (5) and dihydrodehydrodiconiferyl alcohol (6), which were isolated for the first time from this plant. Most of these compounds showed cytotoxicity against human colon carcinoma (HCT-116) and human hepatocellular carcinoma (HepG2) cell lines in vitro, with IC50 values ranging from 19.1 to 71.3 μ g/mL.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/BF02980211

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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