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Title 

Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum thunb.

Authors 

S G ChoiJ KimN D SungKwang Hee SonH G CheonK R KimByoung-Mog Kwon

Publisher 

Taylor & Francis

Issue Date 

2007

Citation 

Natural Product Research, vol. 21, no. 6, pp. 487-493

Keywords 

anthraquinonesCdc25B phosphatasepolygonum multiflorumanthraquinone derivativepolygonum multiflorum extractprotein tyrosine phosphatase inhibitorplant rootpolygonumenzyme inhibitors

Abstract 

Three anthraquinones, Cdc25B phosphatase inhibitors, were isolated from the methanolic extract of the roots of Polygonum multiflorum Thunb. (Polygonaceae). Anthraquinones, physcion (1), emodin (2), and questin (3), inhibited the enzymatic activity of Cdc25B phosphatase with IC50 values of 62.5, 30, and 34 μg mL-1, respectively. Emodin (2) and questin (3) strongly inhibited the growth of human colon cancer cells, SW620 with GI50 values of 6.1 and 0.9 μg mL-1, respectively. Commercially available anthraquinones, chrysophanol (4), and rhein (5) also inhibited Cdc25B phosphatase with IC50 values of 10.7 and 22.1 μg mL-1, respectively.

ISSN 

1478-6419

Link 

http://dx.doi.org/10.1080/14786410601012265

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2017-04-19


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