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Title 

Kaurane diterpenoids from Isodon excisus inhibit LPS-induced NF-κB activation and NO production in macrophage RAW264.7 cells

Authors 

S S HongS A LeeX H HanH Z JinJ H LeeD LeeJung Joon LeeJ T HongY KimJ S RoB Y Hwang

Publisher 

American Chemical Society

Issue Date 

2007

Citation 

Journal of Natural Products, vol. 70, no. 4, pp. 632-636

Keywords 

diterpenoidexcisusinimmunoglobulin enhancer binding proteininflexanininflexarabdonininflexininflexinolkaurane derivativeanimal cellcell line

Abstract 

As part of an ongoing search for plant-derived compounds that inhibit the activation of NF-κB, the methanol extract of the aerial parts of Isodon excisus was found to have significant inhibitory effects on the activation of NF-κB in murine macrophage RAW264.7 cells. Bioactivity-guided isolation of the extract yielded five new diterpenoids, excisusin A-E (1-5), along with seven known compounds, inflexarabdonin I (6), inflexarabdonin G (7), inflexin (8), inflexanin A (9), inflexanin B (10), inflexinol (11), and inflexarabdonin A (12). The structures were determined by analysis of the spectroscopic data including 2D NMR. All of the isolates were evaluated for their inhibitory effects on LPS-induced NF-κB activation and nitric oxide production in RAW264.7 cells.

ISSN 

0163-3864

Link 

http://dx.doi.org/10.1021/np060638+

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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