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Title 

Quinolone alkaloids from evodiae fructus and their inhibitory effects on monoamine oxidase

Authors 

X H HanS S HongD LeeJung Joon LeeM S LeeD C MoonK HanK W OhM K LeeJ S RoB Y Hwang

Publisher 

Pharmaceutical Society of Korea

Issue Date 

2007

Citation 

Archives of Pharmacal Research, vol. 30, no. 4, pp. 397-401

Keywords 

evodia rutaecarpaevodiae fructusmonoamine oxidase inhibitorquinolone alkaloidrutaceaealkaloidquinolone derivativealkaloidsmonoamine oxidase inhibitors

Abstract 

1-Methyl-2-undecyl-4(1H)-quinolone (1) was previously isolated as a selective MAO-B inhibitor from the Evodiae Fructus. Further bioassay-guided purification led to the identification of five known quinolone alkaloids, 1-methyl-2-nonyl-4(1H)-quinolone (2), 1-methyl-2-[(Z)-6-undecenyl]-4(1H)- quinolone (3), evocarpine (4), 1-methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)- quinolone (5), and dihydroevocarpine (6). All the isolates showed more potent inhibitory effects against MAO-B compared to MAO-A. The most MAO-B selective compound 5 among the isolates inhibited MAO-B in a competitive manner, according to kinetic analyses by Lineweaver-Burk reciprocal plots.

ISSN 

0253-6269

Link 

http://dx.doi.org/10.1007/BF02980210

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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