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Title 

Fumimycin: a peptide deformylase inhibitor with an unusual skeleton produced by Aspergillus fumisynnematus

Authors 

Y J KwonMi Jin SohnChang-Ji ZhengWon Gon Kim

Publisher 

American Chemical Society

Issue Date 

2007

Citation 

Organic Letters, vol. 9, no. 13, pp. 2449-2451

Keywords 

amidasebenzofuran derivativefumimycinpeptide deformylaseaspergilluschemical structuredrug antagonismmetabolismstaphylococcus aureus

Abstract 

Fumimycin, an unusual metabolite incorporating an unuaual alanine unit linked to a phenyl group at the α-carbon with both lactone and amide moieties, was isolated from cultures of Aspergillus fumisynnematus. Its structure was established by spectral analysis. Fumimycin was found to Inhibit Staphylococcus aureus peptide deformylase with an IC50 value of 4.1 μM and also showed antibacterial activity against S. aureus.

ISSN 

1523-7060

Link 

http://dx.doi.org/10.1021/ol0703231

Appears in Collections

1. Journal Articles > Journal Articles

Registered Date

2019-05-02


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